Abstract
The effect of glycyrrhetinic acid (GA) and GA-derivatives towards 11beta-hydroxysteroid dehydrogenase (11beta-HSD) was investigated. Novel compounds with modifications at positions C-3, C-11 and C-29 of the GA skeleton were prepared. Single crystal X-ray diffraction data of selected substances are reported and discussed.
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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11-beta-Hydroxysteroid Dehydrogenases / antagonists & inhibitors*
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11-beta-Hydroxysteroid Dehydrogenases / metabolism*
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Crystallography, X-Ray
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Glycyrrhetinic Acid / analogs & derivatives*
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Glycyrrhetinic Acid / chemical synthesis
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Glycyrrhetinic Acid / pharmacology*
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Humans
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Metabolic Diseases / drug therapy*
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Models, Molecular
Substances
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11-beta-Hydroxysteroid Dehydrogenases
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Glycyrrhetinic Acid